{"id":4448,"date":"2016-09-07T20:52:00","date_gmt":"2016-09-07T20:52:00","guid":{"rendered":"https:\/\/www.donotdestroy.com\/index\/150075162402-2\/"},"modified":"2026-02-01T07:20:41","modified_gmt":"2026-02-01T00:20:41","slug":"150075162402-2","status":"publish","type":"post","link":"https:\/\/www.donotdestroy.com\/index\/150075162402-2\/","title":{"rendered":"150075162402"},"content":{"rendered":"

How does cannabis itself work in the pineal gland?<\/h1>\n

Research on rats has shown that the pineal gland contains a functional endocannabinoid system<\/a>,
\n in that cannabinoid receptors type 1 and 2, and the endogenous ligands
\nthat bind to them, anandamide and 2-AG, are all present.<\/p>\n

The study showed that the activity of the CB?-receptors varied
\naccording to a daily cycle, with lowest activity levels occurring at the
\n end of the daylight period. It also showed that levels of an enzyme
\nresponsible for synthesizing new endocannabinoid molecules, NAPE-PLD,
\nwas reduced during the middle of the dark period.<\/p>\n

Furthermore, the study showed that presence of THC reduced the
\nactivity of an enzyme known as AANAT, and in doing so reduces the
\nsynthesis of melatonin itself. An earlier study on rats<\/a>
\n also showed that THC reduced the activity of AANAT, and suggested that
\nthe mechanism that occurred was as follows: the neurotransmitter
\nnorepinephrine starts a cascade of reactions, the end result of which is
\n the production of melatonin. THC disrupts this norepinephrine cascade
\nand thereby reduces the production of melatonin.<\/p>\n

It is likely that THC\u2019s endogenous analogue anandamide performs the
\nsame action of reducing the norepinephrine-induced release of melatonin,
\n and is therefore fundamentally involved in pineal gland function. It
\nseems that low levels of anandamide or THC are therefore needed in order
\n for melatonin production to increase. As melatonin levels increase, as
\nthey should normally do at the end of the daylight period, feelings of
\nsleepiness should occur.<\/p>\n","protected":false},"excerpt":{"rendered":"

How does cannabis itself work in the pineal gland? Research …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12749],"tags":[114,4780,3394,2828,2116,6292,2969,4170,2781,2779,6518,704,1535,3,617,583,890,1544,4347,6519,6520,2780],"class_list":["post-4448","post","type-post","status-publish","format-standard","hentry","category-tumblr","tag-114","tag-biology","tag-blunt","tag-bong","tag-brain","tag-cannabis","tag-conciousness","tag-human-behavior","tag-joint","tag-marijauna","tag-pineal-gland","tag-psychology","tag-quote","tag-quote-of-the-day","tag-quotes","tag-science","tag-smoke","tag-spirituality","tag-thc","tag-the-seat-of-the-soul","tag-third-eye","tag-weed"],"yoast_head":"\n150075162402 - Do Not Destroy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.donotdestroy.com\/index\/150075162402-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"150075162402 - Do Not Destroy\" \/>\n<meta property=\"og:description\" content=\"How does cannabis itself work in the pineal gland? 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